Device and method for implanting an endoprosthesis

专利摘要:

公开号:DK200800058U1
申请号:DK200800058U
申请日:2008-03-31
公开日:2008-06-13
发明作者:Boudjemline Younes；Bonhoeffer Philipp
申请人:Boudjemline Younes；Bonhoeffer Philipp；
IPC主号:

专利说明:

in DK 2008 00058 U3
DEVICE FOR IMPLANTING AN ENDOPROTHESIS
DESCRIPTION
TECHNICAL FIELD
The present invention relates to a device for implanting an implant.
The problem underlying the invention relates to the implantation of heart valves. Until recently, this required open-heart surgical intervention with steps such as stopping the heart, initiating extracorporeal blood circulation, and restarting the heart after implantation of the replacement heart valves. These surgical procedures are difficult and sensitive and present 10 fatal risks associated with surgical shock.
PRIOR ART
Thus, in U.S. Patent No. 5,824,063, a device carrying replacement heart valves is disclosed which comprises a tubular implant of a synthetic material which internally carries a replacement valve of a natural material.
Documents US Patent No. 5,855,601 and U.S. Patent No. 5,868,783 disclose new cardiac valve implantation methods that offer the advantage of avoiding open-heart surgical procedures. These methods provide implantation by passing through the blood circulation system of a replacement heart valve device comprising a radially expandable intravascular cylinder carrying a biological valve internally. An inflatable portion of a balloon catheter is placed inside the supporting cylinder, and the implantation is performed by introduction into a vein and delivery to the failing valve using a catheter. A two-dimensional screen display allows detecting whether the supporting cylinder has reached the desired position, and the cylinder is then played out by inflating the balloon through the catheter and retaining its expanded shape. The air is then released from the balloon and this 2 together with the catheter is removed. The supporting cylinder has a tight sheath which is thus placed against the arterial wall so as to prevent the blood flow from passing through the replacement valve.
However, in the case of aorta, this procedure is not applicable because the coronary arteries open close to the failing native valves, so that the load-bearing cylinder is likely to block them, thereby causing the patient's death.
OBJECT OF THE INVENTION
The inventors of the present application have therefore contemplated providing two corresponding openings in the wall of the casing of the supporting cylinder. However, in order for these openings to be positioned against the two coronary arteries, the position of the supporting cylinder in the aorta must be fully controlled. Monitoring on the screen makes it possible to control the advance, or the axial position, of the bearing cylinder, but the angular position will not be visible or controlled.
Applicants have therefore found a solution described below which allows checking the position of the supporting cylinder.
They have therefore considered the solution of the more general problem of placing an implant or transport device in a tubular element with difficult access and for which imaging is inadequate or even impossible. The field of application can therefore relate to areas other than the medical, such as the oil or nuclear industry, for the purpose of installing sensors, valves, etc. The scope of the present invention should therefore not be considered as limited to the solution of the original problem. The invention is more generally aimed at enabling placement in a readily accessible location of a tubular element of a device intended to carry an implant, regardless of the implant's function.
SUMMARY OF THE INVENTION
3 DK 2008 00058 U3
For this purpose, the invention relates firstly to a device for implantation in a particular position of a tubular element with a wall comprising a cavity, which device is adapted to cooperate with means for advancing the device in the tubular element, a device which is characterized in that it comprises sensors which are deformable and arranged so that, under the control of remote control means, it switches from a collapsed to an unfolded functional form, to detect the cavity and position itself there with reference to the position of the cavity.
Thus, it is possible to feed the device in the blind, and the sensors make it possible to automatically detect the cavity and place in it.
Thus, it is possible to gain access to the final required position, even through a narrowing of the tubular member, for example, the access species leading to a larger diameter artery.
BRIEF DESCRIPTION OF THE DRAWINGS
The characteristics and advantages of the present invention will become more apparent from the following description of a particular embodiment of the device according to the invention and a variant with reference to the accompanying drawing, in which: - Figure 1 is a side sectional view of the device according to the invention, showing - and the anchoring elements, connected to a cylinder carrying a valve prosthesis, where it is all covered by two removable concentric actuating casings, - Figure 2 corresponds to Figure 1, where the sensor placement and anchoring elements are radially unfolded by axial retraction of the external casing, - Figure 3 corresponds to Figures 1 and 2, with the supporting cylinder surrounded by positioning and anchorage sensing elements which are unfolded radially after axial retraction of the internal sleeve, 4 DK 2008 00058 U3 - Figure 4 is a side view of the supporting cylinder and positioning means. and the anchor sensor elements, - Figure 5 is an illustration Fig. 6 is a schematic front view of the device according to the invention; and - Fig. 7 is a schematic cross-sectional side view of the variant.
DETAILED DESCRIPTION
As shown in Figure 1, the present exemplary embodiment corresponds to the medical problem explained at the outset with the implantation of a functioning native aortic valve. The valve 10 implant assembly comprises a support member 20 for receiving the implant associated with a plurality of sensing elements or finger elements 30, 31, which are regularly spaced angularly throughout, for placement and anchoring relative to a relief. specifically, a cavity in the aortic wall, which device 10 is removably connected to a location catheter 60. The device 10 is connected to two concentric sheaths 41, 42 for successive remote control by radial expansion of the sensing elements 30, 31 and then the carrier element 20. The direction of delivery of the device 10 is therefore towards 1 to 3. Reference 62 represents a axis of symmetry and direction of delivery of device 10 and catheter 60.
The implant valve forms a prosthesis 1 comprising valve flaps 2, whose shape and size in the operating position correspond perfectly to the native aortic valves 50 (Figure 2). The prosthesis 1 is attached to the supporting feeding element 20 for receiving the implant, here consisting of a cylindrical wire mesh of a biologically compatible material such as steel, gold alloys and preferably as here nitinol, consisting of a nickel-titanium alloy with mold memory capable of being recovered. its shape after the first deformation, here by radial compression. The attachment of prosthesis 1 to the cylindrical nitinol wire 20 takes place at well-defined locations whereby the regions corresponding to the valve flaps 2 after unfolding from the collapsed position of Figure 2, as illustrated below with respect to Figure 3, are kept free.
Figure 4 shows the cylindrical wire mesh 20 in the unfolded form, carrying the valve flaps 2 also unfolded internally, to which the sensing elements 30, 31 are fixed, here in the form of a generally cylindrical outer ring of wire loops, of which at least one (31), here in fact three, protruding laterally onwards, opposite to the catheter 60. In this example, the loops 31, in the unfolded position, extend in a direction inclined about 30 degrees forward (direction of the target position) relative to the axis 62 of the wire mesh 20 and the ring 30 The sensing elements 30, 31 are connected to the cylindrical wire mesh 20 in such a way that their axial and angular positions with respect to it are perfectly defined. The unit, cylindrical wire mesh 20 and sensor elements 30, 31, consists here of the aforementioned automatically expandable biocompatible material.
The cylindrical supporting wire mesh 20 is here covered by an impervious jacket 21, which is intended to be pressed against the aortic wall to prevent blood circulation from passing through.
Figure 5 shows the sensor elements 30, 31 in perspective. Figure 6 is a schematic illustration along an axial direction of the device 10 showing the three loops 31 projecting laterally from the tubular grid 20 carrying them while the valve flaps 2 of the valve to be implanted are secured internally to the support. cylinder 20.
In addition, if necessary, an inflatable balloon 3, in solid communication with the catheter 60, within the supporting cylinder 20 can be placed for filling with fluid under pressure through catheter tubes 60 so as to effect or contribute to the radial expansion of the catheter 60. bearing cylinder 20 to the desired unfolded shape.
Since the sensor elements 30, 31 are made of an automatically expanding material, such as nitinol, or a corresponding element forming an elastic protruding foot or finger, device 10 is covered by a holding sleeve 42 for holding the sensor elements 30, 31 in a collapsed position where the loops 31 are folded on the ring 30 and as a result also on the wire mesh 20. The sheath 42 extends to cover the catheter 60. Another sheath 41, of substantially the same length and without effect on the sensing elements 30 , 31, is similarly provided to hold the supporting cylinder 20 in the folded position so as to avoid unintended unfolding even in the absence of inflating the balloon 3. The two sheaths 41, 42 are mounted concentrically on the catheter 60. access to the sheaths 41 and 42 from the end of the catheter 60 opposite the device 10. The elements 3, 41, 42, and 60 constitute a functional catheter assembly which comprises is separated from the device 10, for placement and commissioning of the latter and its payload (2).
The two casings 41, 42 inhibit the radial unfolding of structure 20, 30, 31 until the latter reaches the region of the native aortic valve 50 to be functionally replaced and, as a result, allows introduction of device 10 into the blood circulation system, such as an incised artery with reduced diameter. As indicated, the catheter 60, with the balloon 3, is removably attached to the implantation device 10 so as to enable axial delivery of the implantation device 10 into the blood circulation system up to the implant placement and retraction of the catheter assembly 3, 41, 42, 60.
For release, the catheter 60, in this example, at the end attached to the supporting cylinder 20, comprises a plunger of spring effect (not shown), with remote controlled teeth, mounted to be able to rotate radially, for fixed connection to the device 10 and has a sliding center remotely controlled metal wire to axially push the tangs or teeth back of the forceps to radially separate them, thus releasing catheter 60 from implant device 10 according to the sugarcane principle.
As the cylindrical wire mesh 20 is unfolded, the pressure on the inner wall of the aorta is provided by the effect of the shape memory, which consequently ensures the radial expansion of the prosthesis 1. The failing native valve flap 50 is flattened by pressing against the tubular grid 20 against the aortic inner wall. each of the three loops 31 projecting laterally as the previous 7 DK 2008 00058 U3 has been engaged in one of the three native valve flaps 50 and correspondingly pressed to confirm the anchorage. As a result, the valve flaps 50 are clamped between the wire mesh 20, 30 and the respective loops 31.
According to the preferred embodiment, the implantation method of device 10 described above comprises the following steps. After insertion of the implant device 10 into the circulatory system and after pushing it using the catheter 60 to a position on the upstream side of the final target position, precisely where the device 10 arrives in the aorta and so that a larger diameter space is offered to it, the following steps consist in releasing the lateral loops 31 which are initially pressed against the folded wire mesh 20, 30. The release of the loops 31 is effected by retraction of the outer retaining sheath 42 (FIG. 2), i. retraction while maintaining pressure against catheter 60. While the delivery of the device 10 continues, the loops 31, which then project laterally forward relative to the axial direction of the delivery, opposite the catheter 60, form a tripod and simultaneously penetrate the three respective native valve flaps 50 which are substantially identical, with they form an arrangement of connecting pockets in a complete ring, each extending over 120 degrees, thus occupying the entire circumference of the inner aortic wall 51. Each native valve flap 50 has a rounded bottom.
Each lateral projection 31 facing forward is pressed against the bottom of said native valve flap 50, generally at a given point at a distance from the "lowest" point of that bottom, i.e. as a result, the axial advance of the device 10 continues with the pressure of the catheter 60, whereby the axial pressure of the device 10 causes it to slip to the lowest point. As a result, the bottom of the valve flap 50 is a form of guide path or inclined plane (not perpendicular to the axis of the aorta (62)) which, in response to the axial drive force, produces a peripheral reaction force which causes the rotation of the device 10. until the respective feeder loop 31 reaches the lowest point corresponding to a complete end wall (with tangent plane perpendicular to the axis (62) of aorta 51), and 8 consequently corresponds to the final desired axial position and angular position of the device 10th
Thus, each lateral projection 31, with rounded ends, here as a loop, for sliding at the bottom of the valve flap 50, by continuously cooperating with the rounded bottom of the native valve flaps 50 of variable depth continuously, is a rotational feed means for the sensing elements 30, 31 and, consequently, also to the cylindrical wire mesh 20 with which it is firmly connected. However, if the lateral projections 31 encounter a native valve flap 50, the implant 10 may be slightly retracted and the operator may twist the catheter 60 so that it rotates at an angle to be able to restart the placement and anchoring operation.
Accordingly, when the unit, sensor elements 30, 31 and the cylindrical wire mesh 20 are located axially and at an angle to the specific relief of the aorta that the native valve flaps 50 constitute, it is automatically positioned relative to the two coronary artery openings (52) if axial position and angular position relative to the valve flaps 50 are determined and known, the axial distance between the valve flap coronary arteries obviously depending on the size of the patient.
In the case considered here, in which the three native valve flaps 50 form a circular circumference with respect to the aortic wall extending over 360 degrees, a single lateral projection 31 is sufficient for 120 degree modulus placement and anchoring of the cylindrical wire mesh 20. As indicated. above, in a general case, there may be only a single sensor 30, 31 which cooperates with a plurality of voids or pockets covering the entire circumference of the tubular member, or even a single pocket or void 50 occupies only one sector of the circumference and one number of sensors 30, 31 all the way around device 10 so that one of them cooperates with the cavity.
It will be noted, in the present example, that the location of a 120 degree modulus can be tolerated, with the two coronary arteries (52) naturally having substantially this angle. If not, it would be necessary laterally to extend two openings or incisions 22 provided in the sheath 21 such that they were located opposite the coronary arteries (52) (Figure 4 and position marked on Figure 3.), or again sensing by the sensors 31 the coronary arteries (52), which also form cavities in aorta 51, and no longer feel the native valve valves 50.
This case is similar to the variant described below.
Thus, when positioned, subsequent steps, as shown in Figure 3, consist of unfolding the cylindrical wire mesh 20 carrying the valve flaps 2 internally by retracting the inner retaining sleeve 41, to consolidate anchoring and shifting of the valve flaps 2 to their functional form. . For the clarity of the drawing, especially the projection 31, the wire mesh 20 is shown to be relatively small in diameter, while in fact similar to the aorta 5L, with a small supplement to ensure the desired lateral pressure. Two projections 31 are also shown, although they are actually separated by 120 degrees, with the plane of figure 3 alone intersecting one. For this reason, only a single coronary artery has been drawn (52).
The three protruding loops 31, in themselves, provide a basic anchorage at the bottom of the pockets, which the native valve flaps 50 make up, and ensure the location stability of the prosthesis 1. After a few weeks, fibrous tissue begins to cover the prosthesis 1 in cooperation with the lateral projections 31 to further enhance its attachment.
It will be noted, however, that in the unfolded shape of the sensor elements 3l, it is not necessary for their free ends to be pressed hard against the wall of the aorta 51. It is sufficient that their radial extension is sufficient for them to engage in passage during passage. valve valves 50. For that reason, when the sensor elements 31 are unfolded on the upstream side of the final position, the later axial translation of the device 10, up to this position, without "hard" rubbing suppression, occurs by the portion of the loops 31 on the aortic wall 51. The latter runs thus, there is no risk of damage due to scraping or piercing, the loops 31 being sensors following the aortic wall 51 to detect valve flaps 50. As noted above, feet or tongues with rounded ends may also be suitable.
Consequently, the main function of the sensing loops 31 is not to anchor device 10 in a very fixed manner in aorta 51, since they do not aim to exert a very large radial anchoring pressure. As stated above, this is only a basic anchorage. It is then the radial unfolding of the wire mesh 20 that creates, by shape memory, a definite radial anchoring pressure, which forces the wire mesh 20 under pressure against the aortic wall 51 and, consequently, blocks any relative movement, such as retraction of the device 10, which could be due to blood flow. direction opposite the insertion of device 10. Sensor elements 31 are then functionally redundant. However, they contribute to retaining the position by the valve flaps 2. Since the wire mesh 20 provides a relatively large contact surface with aorta 51, any risk of destruction of the latter is excluded.
The shape memory material makes it possible to accurately determine the radial pressure exerted on aorta 51, the thus increased diameter of the latter being then perfectly defined, eliminating all the risks of excessive radial loading.
It will be noted that the implant device according to the invention can first be implanted alone, without implant or payload, the latter being implanted later thereafter according to the same principle. In such a case, the device according to the invention comprises means for receiving the second coming support for the implant which is arranged to secure placement and anchorage, biting axially at stops and radially with corrective means for angular errors, such as a finger or a cavity intended to cooperate with an element of complementary form in the second support.
In the variant shown in Figure 7, the implant device has the reference 110 and includes functional elements similar to that of device 10 with the same references with a hundred in front 1, which, however, are not all shown for clarity. The cylindrical support member 120 is firmly connected to a laterally projecting sensor element 131 having the same construction type as the support member 120. The sensor element 131 appears precisely in the form of a cylinder folded radially in the resting position. When the device 110 is pushed by the catheter 160, towards the bottom of Figure 7, from a position on the upstream side of the one shown, it engages the coronary artery 52 when its free end is thus released from contact with the internal wall. of aorta 51.
The device 110 thus constitutes a form of fork which is blocked at stops in the fork division between aorta 51 and the coronary artery 52. When the stop position is reached, the two cylindrical members 120, 131 are unfolded by the two respective balloons and form a form of a two. -finger glove.
Thus, during the placement phase, the sensor 131 has a radially collapsed shape, 10 with a reduced diameter that does not jeopardize the coronary artery 52. Thereafter, the sensor 131 is unfolded by inflating the balloon associated with remote control and constitutes a liner, or an inner "jacket" which is pressed against the inner wall of the coronary artery 52 according to the principle explained above for the supporting cylinder 20.
It will be noted, since the elements 120 and 131 each occupy a particular branch 51, 52, that they may be considered functionally equivalent to possibly the two main functions. Each of them may in fact be a carrier load (2) and may also be considered as a sensor, the aorta 51 being (functionally as part of the present invention) considered to be a cavity or branching relative to the coronary artery 52. Thus, the sensors comprise a cylindrical member 131 adapted to change from a collapsed shape to a radially unfolded shape with support against a wall of the cavity, here the coronary artery 52, under the influence of remote controlled means (balloon and catheter 160).
In order to avoid the risks of the sensor 131's switching to coupling position to the coronary artery 52 due to an angular displacement which may require multiple attempts, consideration may be given to passing a guide wire into the coronary artery 52 and the portion upstream of aorta 51, which device 110 is inserted over the sensor 131, which is angular in the direction of the coronary artery 52. Another guide wire 30 can simultaneously guide the cylinder 120 into the aorta 51.

权利要求:
Claims (9)
[1]
An apparatus for implanting an implant (2) at a particular position in a tubular member (51) with a wall comprising a cavity (50, 52), which device (10) is adapted to cooperate with means for delivery (60). ) of the device in the tubular element (51), characterized in that it comprises sensors (30, 31, 131) which are deformable and adapted to change from a collapsed control by remote controlled means (42) shape into a functional unfolded shape, to detect the cavity (50, 52) and to position itself there with reference to its position.
[2]
Apparatus according to claim 1, wherein the sensors (30, 31) are made of a material with mold memory.
[3]
Device according to one of claims 1 and 2, wherein the remote controlled means are detachable and comprise a retention sleeve (42) for retaining the sensors (30, 31) in the folded form, the sleeve extending beyond the sensors (30, 31). for releasing them by relative retraction of the sheath relative to a thread element (60) for pushing the device by push.
[4]
Device according to one of claims 1 to 3, wherein the sensors (30, 31) comprise a ring, generally cylindrical in shape with a radial direction, of loops (31) made of a thread with a limited stiffness in the radial direction, in which at least one of the loops (31) is arranged to appear laterally so as to form a sensor.
[5]
Apparatus according to any one of claims 1 to 4, wherein the sensors (30, 31) comprise a plurality of sensing fingers (31) which are regularly distributed angularly and arranged so that, in the unfolded form, they extend in respective inclined directions. at acute angles on a longitudinal feed axis (62) forward from the device in the direction of the cavity (50).
[6]
Apparatus according to one of claims 1 to 5, wherein the sensors (30, 31) are connected with deformable receiving means (20) to an implant (2) arranged so that, under the action of the release means (41), it changes from an Inspicos / 27 / Q6 / 2008 / ll: ll 13 GB 2008 00058 U3 folded shape into a radially unfolded shape, with pressure against the wall of the tubular element (51) and use of the implant (2).
[7]
Device according to claims 3 and 6 together, wherein the means (20) for receiving the implant (2) comprises a wire mesh in a generally cylindrical shape with an axial direction for carrying the implant, with a limited stiffness in the axial direction, and the release means includes a movable sleeve (41) for holding the supporting wire mesh (20) in the folded position, extending axially beyond the wire mesh to release it by a relative axial retraction of the sleeve (42) relative to a thread member ( 60) for advancing the device at a push, the inhibition and retention sleeves (41, 42) being concentric.
[8]
Apparatus according to one of claims 6 and 7, wherein the means for receiving (20) an implant is covered by a lateral sealing sheath (21) intended to be pressed against the wall of the tubular element (51) by means of these, and the sheath (21) at least comprises an aperture or incision (22) which occupies an angular position determined relative to the sensors.
[9]
Device according to any one of claims 1 to 8, wherein the sensors (131) comprise a cylindrical element adapted to change from a collapsed shape to a radially unfolded shape, supported against a wall of the cavity (52) under the influence of remote control means. .

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法律状态:
2012-08-10| UUP| Utility model expired|

优先权:

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申请号 | 申请日 | 专利标题

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FR0110444A|FR2828263B1|2001-08-03|2001-08-03|DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE|

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